#COLONCANCER & #AYURVEDA

 Ayurveda talks of 3 humoral principles of constitution of matter formed out of 5 basic elements, both for living and non-living.

The three are - viz., Vata. Pitta, Kapha. These have been textually translated as air, bile and phlegm. This basic translation is wherefrom the whole goes wrong in conveying the right message.

Question - Why wrong?

Answer - this is a molecular representation which has been universalized to both living and non-living and therefore to give it a perfect nomenclature and representation is an imperfect attribution.

Question - Then what should be the representation?

Answer - These are abstract attributes which find morphological or physiological interpretations in modern science to make it easy for people to understand because of change of language of communication with time. 

Vata - basically represents dynamism and anything which reflects as motion, including the vibration between the intermolecular spaces of a solid is vata.

Pitta - is reflected in the cause of these motions increasing or decreasing. 

The increasing or decreasing thresholds of energy causing the motion as one reflection is a representation and further relates to changing forms of energy.

Kapha - is the resultant reflection of change of states of matter because of changes in energy thresholds and induced alterations in dynamism of the intermolecular and atomic spaces.

Now let me first bring it to a living body or at best a living cell. 

Vata - in case of cell may be reflected in the motion of molecules entering or leaving the cell and movement of cytoplasmic or nucleopplasmic fluid within etc.

This is enabled by 4 forms of energy to be understood in different ways - electrolytic potential, pressure gradient of osmosis, energy changes within due to biomolecular reactions happening,and energy changes happening in terms of pH of the environment which by itself is competitive enough to run the biomolecular bilateral reaction of catabolism and anabolism together, with one overtaking the other along with the process of ageing.

Therefore - Ayurveda is a cosmic interpretation of energy dynamics in one way which in large spaces stands misinterpreted as a plain morphological science.

Will be taking up cancer and then colon cancer in a short while. on this thread itself.

#Cancer - basic definition suggests - uncontrolled multiplication of cells. 

Known researches in modern science suggest - while a lowered pH enables multiplication of cells, and increasing one which means alkalination enhances maturation and differentiation.

This is reflected in #Ayurveda and is corelated by 2 elements of observation - 

1) increased multiplication induces anaerobic stress and the resultant metabolic products are of acidic pH.

2) Maturation and differentiation is enabled by cations which is alkalination.

Ayurveda - suggests multiplication is vata (dynamic) and anaerobic or aerobic function to be energy translation of (agni = pitta) when agni which is a component of pitta is less and need is more the stress is on the process leading to anaerobic state. 

The above conclusion is similar to modern medicine where if there is not enough oxygen or any other oxidative anion, the process moves from a ATP profiteering state to ATP loss and absence of anions leads to increased acidification.

This is used to be called as aerobic and anaerobic stress and now in modern cellular and molecular biology it has been represented by molecular thresholds at the levels of ER and Mitochondria and Golgi and, thereby reported as organelle level metabolic stress function.

This difference is acceptable and should not become a discord as often in discourse as 3000 years ago we did not have microscopy or spectrography or chromatography or radiography or any other such mapping technique which could map these processes the same way as we do today.

Back to cancer - so when there is a loss in this linear moderation of pH within the body moving from Acid to Base, it causes cellular injuries. These injuries can be to the mRNA chain, to cell structure, to cell fluid environment.

When the damage is to the mRNA it can trigger an autoimmune reaction and also may be cancer. When there is a structural injury it impairs mechanisms like cell adhesion which prevent further cell multiplication and induce differentiation and maturation, and when the damage is to the fluid environment this is hyperdynamic and can cause simultaneous repeated injuries of both kind and therefore has the potential to cause cancer in the most notorious of forms.

Ayurveda - treats this as an imbalance of agni due to absence of jal and prithvi - (hydroxylation and cataionic imbalance) which may be because of impaired micronutrition, poor water intake

and many other reasons leading to creation of an environment which induces a hyperdynamic response with multiple injury points and leads to formation of physical nodes sometimes and sometimes dynamic patches called as Arbud. which have there own classification of subtypes.

So the basic aetiology is somewhere similar in altered biochemical environment due to causes which may not be pin pointed in either systems and made an assumption of as to what can lead to a cancer.

Synergistic approach to use of diagnostic tools will make it more coherent and treatment options more specific.

I shall be picking specifically on #coloncancer shortly on this thread itself next.

Coming to #ColonCancer I will use the following modern medicine link to share my views -https://www.mayoclinic.org/diseases-conditions/colon-cancer/symptoms-causes/syc-20353669

Key points that i would address - 

1) polyps and why they form as per Ayurveda

2) similarities of causes underlying for colon cancer between modern medicine and Ayurveda

3) possible role of ayurvedic drugs

I will begin with second point - similarities.

Modern - 

In general, colon cancer begins when healthy cells in the colon develop changes (mutations) in their DNA. A cell's DNA contains a set of instructions that tell a cell what to do.

Ayurveda - 

DNA mutations need altered enzyme behaviour which has to do with pH and Cationic and Anionic exposure within the cell environment. This point is the same as discussed above. 

Ayurveda relates this due to lack of coherent knowledge of the time to 5 element theory and 3 principles

Modern - Healthy cells grow and divide in an orderly way to keep your body functioning normally. But when a cell's DNA is damaged and becomes cancerous, cells continue to divide — even when new cells aren't needed. As the cells accumulate, they form a tumor.

Ayurveda - when there is a pittaja imbalance inducing vata and both enter into a cyclic induction or anaerobic stress, lead to altered biochemical behaviour and altered mRNA transcription preceeded by a mutation, and hence altered mitotic cycle or may be meiosis as well.

With time, the cancer cells can grow to invade and destroy normal tissue nearby. And cancerous cells can travel to other parts of the body to form deposits there (metastasis).

This is hyperdynamism of Vata when it starts consuming water as a whole and dries out intercellular spaces causing both anasarca and emaciation depending on locus and in all forms it is terminal

coming to polyps - benign and malignant - 

polyps in Ayurveda are principally kaphaja state where they remain benign and are clumps of cells to say. This is a state where textually the 5 element theory says - 

Prithvi and Jal increase which means mass increase which is benign. 

this leads to obliteration of akash or space, physically observed phenomenon. Akash is both abstract and morphological obliteration of space with growing polyps.

A growing polyp always potentially can cause 

1) stool obstructions, small or large

2) stool adhesion around which means increased putrefaction at the site

3) increased ammonia at the polyp site leading to cationic substitution causing local electrolytic imbalances 

4) impaired transmembrane transport, inducing altered mRNA transcription, mutation and development of polyps as multiplication gets altered.

5) Ayurveda elaborates on the biochemical physiology of it instead of much on morphology

6) Altered pittaja behaviour (Agni supposedly fire) leads to altered ratios of (jal supposedly water), (prithivi supposedly solid state matter) and (akash supposedly space). 

This induces altered dynamic factor (vayu supposedly air) 

7) the two dynamic factors agni and vayu induce movement across the environment of the 3 physical attributes and there limitation unnaturally. 

8) consequent desiccation leads to further concentration of pitta and vata manifested as cationic substitution.

9) till water is present prithivi and jal combine to form adhered clumps called arbud, but following desication this disintegrated or as we call as bursts and therefrom it becomes free to move about or metastasis.

10) therefore it is largely different routes of explanation

Risk factors

Older age. Colon cancer can be diagnosed at any age, but a majority of people with colon cancer are older than 50. The rates of colon cancer in people younger than 50 have been increasing, but doctors aren't sure why.

Ayurveda - with growing age oxidative stress ..

increases leading to tissue level acidity or aam dosha as we call and this is an underlying part of ageing and also autoimmunity. 

both lead to certain susceptibilities including cancer.

African-American race. African-Americans have a greater risk of colon cancer than do people of other races.

 Ayurveda - details this as part of a concept which it calls as prakruti and is a detailed meta analysis of all conditions that influnence human health

A personal history of colorectal cancer or polyps. If you've already had colon cancer or noncancerous colon polyps, you have a greater risk of colon cancer in the future.

Ayurveda - answers this as altered prakruti within which needs close management

Inflammatory intestinal conditions. Chronic inflammatory diseases of the colon, such as ulcerative colitis and Crohn's disease, can increase your risk of colon cancer.

Ayurveda - these conditions have an altered inflared vata or pitta or both and hence a predisposition

Inherited syndromes that increase colon cancer risk. Some gene mutations passed through generations of your family can increase your risk of colon cancer significantly. 

Ayurveda - relates this to prakruti again

The most common inherited syndromes that increase colon cancer risk are familial adenomatous polyposis (FAP) and Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC).

Ayurveda - Parental prakruti and conceptional prakruti influences

Family history of colon cancer. You're more likely to develop colon cancer if you have a blood relative who has had the disease. 

Ayurveda - Prakruti

Low-fiber, high-fat diet. Colon cancer and rectal cancer may be associated with a typical Western diet, which is low in fiber and high in fat and calories. 

Ayurveda - Inflared Pittaja and Vataja functions leading to altered prakruti is what Ayurveda explains this as

Research in this area has had mixed results. Some studies have found an increased risk of colon cancer in people who eat diets high in red meat and processed meat.

Ayurveda - Poor aerobic metabolism

A sedentary lifestyle. People who are inactive are more likely to develop colon cancer. Getting regular physical activity may reduce your risk of colon cancer.

Ayurveda - poor aerobic metabolism

Diabetes. People with diabetes or insulin resistance have an increased risk of colon cancer.

Ayurveda - Increased metabolic stress both at colon and extra colon levels leading to hyperaltered metabolic oxidative impacts

Obesity. People who are obese have an increased risk of colon cancer and an increased risk of dying of colon cancer when compared with people considered normal weight.

Ayurveda - Impaired oxidative metabolism

Smoking. People who smoke may have an increased risk of colon cancer.

Alcohol. Heavy use of alcohol increases your risk of colon cancer.

Ayurveda - Impaired oxidative metabolism

Radiation therapy for cancer. Radiation therapy directed at the abdomen to treat previous cancers increases the risk of colon cancer.

Ayurveda - external causes altering agni and vayu locally as a traumatic impact

This is what i have to say for now on this subject!

Medicines i have not touched for a while until this discussion closes on twitter